Model fitted: LME or GEE model
log(hormones) ~ Study + GA at sampling + Study:GA at sampling LME only: Random intercepts for Study ID and Plate GEE only: Independence correlation structure
50.2.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
8.706512
1
0.003
**
Study
2.244395
1
0.1
ns
GA_samp
30.790407
1
<0.0001
***
Study:GA_samp
2.221336
1
0.1
ns
hPL (μg/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
46.94900
1
<0.0001
***
Study
21.66283
1
<0.0001
***
GA_samp
94.21469
1
<0.0001
***
Study:GA_samp
25.95307
1
<0.0001
***
GH2 (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
12.13572
1
0.0005
***
Study
16.86104
1
<0.0001
***
GA_samp
53.71079
1
<0.0001
***
Study:GA_samp
17.66908
1
<0.0001
***
Insulin (uU/ml)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
6.440
6.440
0.01
*
3
GA_samp
1
Inf
3.036
3.036
0.08
ns
2
Study:GA_samp
1
Inf
4.677
4.677
0.03
*
HOMA-IR
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
7.472
7.472
0.006
**
3
GA_samp
1
Inf
3.420
3.420
0.06
ns
2
Study:GA_samp
1
Inf
4.874
4.874
0.03
*
Glucose (mmol/L)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
0.232
0.232
0.6
ns
3
GA_samp
1
Inf
0.008
0.008
0.9
ns
2
Study:GA_samp
1
Inf
0.111
0.111
0.7
ns
50.2.2 Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
Var
Effect
P
(Intercept)
1.72 (0.58, 2.87)
0.003
StudySTOP
0.91 (-0.28, 2.10)
0.13
GA_samp
0.21 (0.13, 0.28)
<0.0001
StudySTOP:GA_samp
-0.06 (-0.14, 0.02)
0.14
hPL (μg/ml)
Var
Effect
P
(Intercept)
2.14 (1.52, 2.76)
<0.0001
StudySTOP
-1.51 (-2.15, -0.87)
<0.0001
GA_samp
0.20 (0.16, 0.24)
<0.0001
StudySTOP:GA_samp
0.11 (0.07, 0.15)
<0.0001
GH2 (ng/ml)
Var
Effect
P
(Intercept)
-1.33 (-2.10, -0.56)
0.0005
StudySTOP
-1.64 (-2.45, -0.83)
<0.0001
GA_samp
0.18 (0.13, 0.23)
<0.0001
StudySTOP:GA_samp
0.11 (0.06, 0.17)
<0.0001
Insulin (uU/ml)
Var
Effect
P
(Intercept)
4.31 (2.75, 5.87)
<0.0001
StudySTOP
-2.10 (-3.73, -0.48)
0.01
GA_samp
-0.11 (-0.21, -0.01)
0.04
StudySTOP:GA_samp
0.12 (0.01, 0.23)
0.03
HOMA-IR
Var
Effect
P
(Intercept)
3.01 (1.39, 4.64)
0.0003
StudySTOP
-2.36 (-4.05, -0.67)
0.006
GA_samp
-0.12 (-0.22, -0.01)
0.03
StudySTOP:GA_samp
0.13 (0.01, 0.24)
0.03
Glucose (mmol/L)
Var
Effect
P
(Intercept)
1.67 (1.34, 1.99)
<0.0001
StudySTOP
-0.08 (-0.42, 0.26)
0.63
GA_samp
0.00 (-0.02, 0.02)
0.90
StudySTOP:GA_samp
-0.00 (-0.03, 0.02)
0.74
50.2.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
50.2.4 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
44.67877
9.765118
775.60673
29.09173
68.61720
STOP
10
60.90187
4.717695
79.27188
52.20009
71.05425
SCOPE
16
155.26985
12.165875
82.42309
132.86150
181.45757
STOP
16
147.84441
14.552006
197.53829
121.76053
179.51605
hPL (μg/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
60.06118
6.777997
1013.3294
48.13041
74.94940
STOP
10
39.61791
1.055110
108.7181
37.58090
41.76535
SCOPE
16
194.04839
5.259046
113.7242
183.90473
204.75155
STOP
16
247.31102
10.211412
486.6536
228.03943
268.21126
GH2 (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
1.600762
0.2192977
433.4993
1.222895
2.095387
STOP
10
0.948957
0.0264086
216.5576
0.898308
1.002462
SCOPE
16
4.703807
0.1314798
197.9604
4.451542
4.970366
STOP
16
5.462550
0.2814179
922.9232
4.937259
6.043728
Insulin (uU/ml)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
25.31505
7.1937998
Inf
14.504141
44.18404
STOP
10
10.17569
0.4433112
Inf
9.342878
11.08274
SCOPE
16
13.27781
0.7140309
Inf
11.949565
14.75370
STOP
16
10.90728
1.0191172
Inf
9.082069
13.09930
HOMA-IR
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
6.371755
1.8874508
Inf
3.565455
11.386841
STOP
10
2.137866
0.0979181
Inf
1.954312
2.338660
SCOPE
16
3.173325
0.1800916
Inf
2.839275
3.546678
STOP
16
2.273611
0.2215450
Inf
1.878337
2.752067
Glucose (mmol/L)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
5.361853
0.3217762
Inf
4.766861
6.031111
STOP
10
4.750210
0.0569715
Inf
4.639850
4.863194
SCOPE
16
5.406086
0.0560985
Inf
5.297246
5.517163
STOP
16
4.682279
0.0697641
Inf
4.547522
4.821030
50.2.5 Comparisons
Hormone
Contrast
GA_samp
Ratio of Geometric means (95% CI)
P-value
PRL (ng/ml)
STOP / SCOPE
10
1.36 (0.90, 2.07)
0.1
PRL (ng/ml)
STOP / SCOPE
16
0.95 (0.81, 1.11)
0.5
hPL (μg/ml)
STOP / SCOPE
10
0.66 (0.53, 0.82)
0.0003
hPL (μg/ml)
STOP / SCOPE
16
1.27 (1.18, 1.38)
<0.0001
GH2 (ng/ml)
STOP / SCOPE
10
0.59 (0.45, 0.78)
0.0002
GH2 (ng/ml)
STOP / SCOPE
16
1.16 (1.04, 1.29)
0.007
Insulin (uU/ml)
STOP / SCOPE
10
0.40 (0.23, 0.71)
0.002
Insulin (uU/ml)
STOP / SCOPE
16
0.82 (0.67, 1.01)
0.07
HOMA-IR
STOP / SCOPE
10
0.34 (0.19, 0.60)
0.0003
HOMA-IR
STOP / SCOPE
16
0.72 (0.57, 0.89)
0.003
Glucose (mmol/L)
STOP / SCOPE
10
0.89 (0.79, 1.00)
0.05
Glucose (mmol/L)
STOP / SCOPE
16
0.87 (0.84, 0.90)
<0.0001
50.2.6 Barplots by Study
Barplots in this section may be misleading due to involvement of Study by GA interaction.